Progress of research on NMN aging suppression effects and intestinal health
According to the latest studies published by a research team at Wenzhou Medical University in China, the resolution of Nicotine Amide Mononnonucleotides (NMN) extends the mid -aging mouse's medium -sized mouse by 20 % and restores the intestinal structures. It has been reported that you can. This study is published in the food science and functional food magazine "Food & Function", providing new knowledge on the effects of NMN aging and the impact on intestinal health.
The effects of NMN and its mechanism
NMN is an important precursor that is converted to Nicotine Amiden Jinju Nucleotide (NAD+) in the body. NAD+is an indispensable coenzyme that supports cell energy metabolism and repair function, and is known to decrease with aging. The decrease in NAD+is thought to contribute to the progress of aging and many aging diseases, and is expected to recover the NAD+level by replenishing NMN.
The research team at Kenzhou Medical University examined the effects of NMN in detail using a mouse model with a gene mutation that causes early aging. This mouse model is a model suitable for aging research because it is short -lived than usual and only survives for about 5 months. According to research, oral administration of NMN, it has been confirmed that the average life expectancy of an early aging mouse has been extended by 14 %, the middle life expectancy is 20 %, and the maximum life expectancy is 10 %.
In addition, NMN was administered to a healthy middle -aged mouse, and it was recovered that the intestinal tract was closely connected to a multi -protein complex. This is extremely important for intestinal structural integrity and maintaining functional barriers. Intestinal barriers prevent the invasion of pathogens and harmful substances and play a role in maintaining the health of the body. It has been shown that replenishment of NMN has increased the level of Claudin-1, the intestinal intestinal tumper, about four times, and the intestinal function has been significantly improved.
Impact on intestinal flora
It has become clear that NMN also has a beneficial effect on the intestinal flora. The intestinal flora is closely related to digestive and immune functions and has a significant effect on healthy life expectancy. Research confirmed that the resolution of NMN increased the existence of beneficial intestinal bacteria, such as bifidobacteria and Ackmansia, has increased. Bifidobacteria are known to have anticancer characteristics, indicating that Ackmansian bacteria are associated with longevity. By improving the balance of these intestinal bacteria, NMN can prevent the decline in intestinal function due to aging and improve overall health.
Significance of experiments using early aging mice
The life of a health mouse is about 2.5 years, and research on life takes time and cost. However, early aging mice have a short life, so the effects of NMN can be quickly and efficiently evaluated. In this study, the mid -aging mouse was extended by 20 % and the maximum life was extended by 10 %. This result supports NMN's promising effects in other aging -related diseases models.
For example, it has been reported that the middle life has been extended by about 3.5 % by replenishment of NMN even in muscle atrophy side sclerosis (ALS) model mice. The ALS model mouse did not observe the maximum extension of the maximum life, but the early aging mouse has a remarkable extension effect. These results show the potential for NMN as a treatment for aging -related diseases and aging decline.
NMN and human healthy life expectancy
At present, the effects of NMN are mainly confirmed by mouse models, but research to verify human effects is underway. Like NMN, nicotine amidenucleotide (NR) also functions as a precursor to NAD+, and is expected to compensate for the decrease in NAD+associated with aging. NR has shown that it has a therapeutic effect on age -related neuropolics, cardiovascular diseases, and metabolic diseases, but has not been confirmed to extend the life of a healthy mouse.
Regarding NMN, while the extension effect of early aging mice has been confirmed, research to determine the effects on healthy elderly mice has become a future issue. If NMN extends the life of healthy mice, a way to further test NMN's potential in humans will be opened. In this regard, NMN is expected to extend the human healthy life expectancy and contribute to the prevention and treatment of diseases associated with aging.
Conclusion
NMN research by the research team at Atsusu Medical University in China provides new knowledge about aging and intestinal health. In experiments using the early aging mouse model, NMN extended the middle life by 20 %, and the effect of recovering the intestinal structure was effective. In addition, it has been shown to improve the balance of intestinal flora and maintain healthy intestinal functions. These results have suggested that NMN may contribute to the treatment and prevention of aging -related diseases, and expectations for future research in the future are growing.
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